Integumentary, Skeletal system & osteoporosis

The integumentary and skeletal systems work together as the bodys first line of defense. As we age, cellular processes slow down and our defenses start to falter. Your task is to explore the functional relationship between these two systems and examine why osteoporosis is a multifactorial disease.

Imagine that you have been asked to write a scientific article to be published in a prominent journal on the topic of osteoporosis as a multifactorial disease. Prepare a written paper of at least 1000 words on the following bullet points:
– What is the functional relationship between the integumentary and skeletal systems?
– How does failure to maintain homeostasis in the integumentary system affect bone formation and remodeling processes? Be sure to discuss how the different types of bone cells respond to different factors (e.g., ions, hormones, cellular signaling molecules, etc.) and what the driving force behind maintaining homeostasis in the bone remodeling process.
– Describe the pathogenesis of osteoporosis and explain why it is considered a multifactorial disease.
– How do current therapies address these failures to maintain homeostasis and ameliorate the effects of osteoporosis?